Instructions to Generate PDF from HTML Paper

Method 1: Using Web Browser (RECOMMENDED for Windows)

Google Chrome / Microsoft Edge (Best Quality)

1. Open the HTML file in Chrome or Edge:

   • Double-click NeuroCHIMERA_Paper.html
   • Or File → Open → Select the HTML file

2. Press Ctrl+P (or File → Print)

3. Configure print settings:

   • Destination: Save as PDF
   • Layout: Portrait
   • Paper size: A4
   • Margins: Default (or Custom: 2cm all sides)
   • Options: Enable "Background graphics"
   • Scale: 100%

4. Click "Save" and choose destination

5. The PDF will maintain the 2-column format perfectly

Firefox

1. Open HTML file in Firefox
2. Press Ctrl+P
3. Select "Save to PDF"
4. Configure:
   • Paper size: A4
   • Orientation: Portrait
   • Print backgrounds: ON
5. Click "Save"

Method 2: Using wkhtmltopdf (Alternative)

If you need command-line generation:

# Download wkhtmltopdf from: https://wkhtmltopdf.org/downloads.html
# Install it, then run:

wkhtmltopdf --page-size A4 --margin-top 20mm --margin-bottom 20mm --margin-left 20mm --margin-right 20mm --enable-local-file-access NeuroCHIMERA_Paper.html NeuroCHIMERA_Paper.pdf

Method 3: Using Python with Playwright (Advanced)

# Install: pip install playwright
# Then: playwright install chromium

from playwright.sync_api import sync_playwright

with sync_playwright() as p:
    browser = p.chromium.launch()
    page = browser.new_page()
    page.goto('file:///d:/Vladimir/NeuroCHIMERA_Paper.html')
    page.pdf(
        path='NeuroCHIMERA_Paper.pdf',
        format='A4',
        print_background=True,
        margin={'top': '20mm', 'right': '20mm', 'bottom': '20mm', 'left': '20mm'}
    )
    browser.close()

Method 4: Online Tools

1. Upload HTML to:

   • https://www.sejda.com/html-to-pdf
   • https://cloudconvert.com/html-to-pdf
   • https://www.sodapdf.com/html-to-pdf/

2. Download generated PDF

Quality Verification

After generating PDF, verify:

• ✓ 2-column format is preserved
• ✓ SVG figures render correctly
• ✓ Tables have proper formatting
• ✓ Equations are readable
• ✓ References are numbered correctly
• ✓ Page breaks don't split figures/tables
• ✓ All colors and gradients are visible
• ✓ Links are clickable (test GitHub, ResearchGate links)

Recommended Settings Summary

• Format: A4 (210 × 297 mm)
• Orientation: Portrait
• Margins: 20mm all sides
• Background Graphics: ENABLED (critical for SVG figures)
• Scale: 100%
• Headers/Footers: None

File Information

• Source HTML: d:\Vladimir\NeuroCHIMERA_Paper.html
• Expected PDF: d:\Vladimir\NeuroCHIMERA_Paper.pdf
• Word Count: ~15,000 words
• Figures: 3 professional SVG figures
• Tables: 6 comprehensive tables
• References: 45 citations with DOIs
• Pages: Expected 25-30 pages in 2-column format

Authors

• V.F. Veselov - Theoretical Framework & HNS (Moscow Institute of Electronic Technology)
• Francisco Angulo de Lafuente - CHIMERA Implementation (Madrid, Spain)

Note on WeasyPrint

WeasyPrint has dependency issues on Windows (requires GTK libraries). The browser method is simpler and produces equivalent or better results. If you're on Linux:

pip install weasyprint
python -c "from weasyprint import HTML; HTML(filename='NeuroCHIMERA_Paper.html').write_pdf('NeuroCHIMERA_Paper.pdf')"